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Each tyrosine kinase antagonists or tyrosine kinase agonists can be classified into groups which target different TK pathways. Anti-Tyrosine kinase activity for each molecule can vary according its structure and the more sensitive it is the less toxicity seems to occur. It is recommended to buy tyrosine kinase inhibitors with great care, prices can vary between $40-50 per 10 mg up to $1500 per 10 mg for the same compound of the same purity. Clinic Therapeutics of tyrosine kinases Of the receptor tyrosine kinase inhibitors under development 12 have been approved (as of 2012) by the FDA and 10 by the EMA for clinical use. The first molecule to be approved was Imatinib for use in Acute Lymphoblastic leukemia (ALL) and chronic myelogenous leukemia (CML) [16-18]. Subsequently Gefitinib was approved for use in NSCLC [19-21], next on the list is Erlotinib which has been approved for NSCLC and pancreatic cancer [22-24]. 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